Geneticist Craig Albertson to Study Shaping of Skull and Facial Skeleton

Evolutionary and developmental geneticist Craig Albertson, biology, has received a five-year, $1.76 million National Institutes of Health grant to study the development of the craniofacial skeleton, work he says will address a significant knowledge gap. Albertson explains, “While we know a lot about how the skull and facial skeleton form, we know comparatively very little about how the head is shaped over development.”

Albertson’s lab will first use a combination of micro-CT scanning, 3D reconstructions and genetic mapping in cichlid fish to generate hypotheses about the specific genes that control head shape variation. Cichlids are famous for their remarkable morphological diversity, including craniofacial diversity, and are therefore an excellent model for such studies, he says. Next, he and colleagues will test these genetic hypotheses by manipulating the genomes of zebrafish, what he calls “a powerful experimental model system,” to look for differences in skull shape.

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