Production of Taxol™ (Paclitaxel) in Plant Cell Cultures

Paclitaxel is a valuable pharmaceutical compound currently used primarily for treatment of cancer, but which has also been found to reduce major adverse cardiac events when coated onto coronary stents, and which is being tested in the treatment of Alzheimer’s disease and other neurodegenerative disorders characterized by altered microtubule networks. The biosynthesis of paclitaxel is complex, and prior to our work in the system, molecular analysis of the system was limited to work on the biosynthetic genes themselves.