Forebrain Defects in Zebrafish yot(gli2)
mutants
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Frontal views of 2 day old zebrafish embryos (anterior up) in which
retinal
ganglion cells
were labeled with the Zn-5 antibody. In wild type embryos (left)
retinal axons cross
the
midline of the forebrain to form the optic chiasm. In yot(gli2)
mutants (right), retinal
axons fail to cross the midline and an ectopic midline
lens forms in place of the pituitary.
Click to learn how our lab is investigating Hh/Gli signaling in
axon
guidance and pituitary
development.