Identification of Novel Metabolites through Biotransformation Assays

The Jung lab is seeking an experienced undergraduate willing to pursue an independent project to investigate the biotransformation abilities of the fungus Sclerotinia homoeocarpa. Sclerotinia homoeocarpa causes dollar spot, which is the most common and economically important disease of cool-season turf grasses. This particular turfgrass pathogen has developed resistance to multiple fungicide classes. Our lab currently researches the genetic mechanisms of fungicide resistance through host induced gene silencing, comparative genomics and molecular approaches.

Circadian rhythms and estrous cycles

A master circadian pacemaker in the hypothalamus controls not only rhythms of sleep and wakefulness but also neuroendocrine functions including the estrous cycle in mice and hamsters. By studying mutants and conditional knockouts, we examine the roles of specific genes and their protein products in the brain circuitry that generates the preovulatory surge of luteininzing hormone (LH) from the anterior pituitary. Projects require handling of animals in order to track estrous cycles, ovariectomy, hormone assays, PCR genotyping, and immunostaining (with quantitative neuroanatomical analyses).

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