Using cutting edge microscopy to study high-speed cell migration

Project Description : 

Cells within your own body crawl over surfaces and through three-dimensional environments. Some cells crawl slowly, while others crawl very quickly. Conventional microscopy is good for imaging slow-moving cells on flat surfaces but cannot keep up with white blood cells like neutrophils that migrate a thousand times faster through 3D environments. To understand how high-speed cells interact with and crawl through complex environments, we use cutting edge lattice light sheet microscopy that has the necessary speed and resolution to image fast-moving cells and complex environments. (A video of the imaged cells can be viewed here https://youtu.be/6ShQUzB5By8). We are also developing analytical tools to track the movements of cells, and how this motion changes their environments.

We are looking for a highly motivated student to help us analyze these data. The student will work closely with both Professor Fritz-Laylin and a data visualization specialist to apply new analysis methods to complex 3D microscopy data sets. Students MUST be available for at least 6 hours per week Monday-Friday between 9 a.m. and 5 p.m. in a minimum of 2-hour blocks. Active participation in group laboratory meetings and bi-weekly one-on-one meetings is required of all lab members. Qualities we are looking in applicants include: curiosity about the project (and cell biology in general), impeccable record keeping, excellent communication and interpersonal skills, and the ability to work both independently and collaboratively on a team. For more information about the lab see: www.fritzlaylinlab.org

Student Ranks Applicable: 

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Name of Lab: 

Fritz-Laylin Lab

Contact Person: 

Professor Lillian Fritz-Laylin

Contact E-mail: 

fritzlaylin@gmail.com

Lab website: 

fritzlaylinlab.org