|Michael J. Barresi
Assistant Professor of Biological Sciences, Smith University
Ph.D.: Wesleyan University
How Glial Cells Help Wire the Nervous System
My research interests are focused on how glial cells help wire the nervous system in the embryonic zebrafish brain. We discovered that astroglial cells provide a substrate for midline crossing axons in the forebrain. Further investigation will attempt to determine how the cellular identity of these astroglial cells is established, what molecular cues control glial cell positioning in the brain and lastly how these astroglial cells actively participate in axon guidance. In order to address these questions, we use zebrafish as a model system.
Deschene ER, Barresi MJ. 2009. Tissue targeted embryonic chimeras: zebrafish gastrula cell transplantation. J Vis Exp. (31).
Michael J. Barresi, Steven A. Farber, Lara D. Hutson, David R. Hyde, Jennifer O. Liang, Jacqueline K. Morris. 2008. Zebrafish in the classroom. Zebrafish 5(3): 205-208.
Barresi MJ, Hutson LD, Chien CB, Karlstrom RO. 2005. Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development. 132(16):3643-56.
Sbrogna JL, Barresi MJ, Karlstrom RO. 2003. Multiple roles for Hedgehog signaling in zebrafish pituitary development. Dev Biol. 254(1):19-35.