Min Chen

Professor of Chemistry, University of Massachusetts

Email: mchen1@chem.umass.edu
Min Chen Chemistry Web Site

Ph.D.: University of Frankfurt, Germany
Postdoctoral Training: University of Oxford, UK

Engineering Protein Pores for Biosensing

Representative publications:

Fahie M, Romano FB, Chisholm C, Heuck AP, Zbinden M and Chen M: A non-classical assembly pathway of Escherichia coli pore forming toxin cytolysin A. J Biol Chem, 2013, 288(43):31042-51.
Zhuang T, Chisholm C, Chen M and Tamm LK: NMR-based conformational ensembles explain pH-gated opening and closing of OmpG channel. J Am Chem Soc, 2013, Oct 9;135(40):15101-13.

Lou H, Chen M, Black SS, Bushell SR, Ceccarelli M, Mach T, Beis K, Low AS, Bamford VA, Booth I, Bayley H and Naismith JA: Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli. PLoS One. 2011, 6(10):e25825.

Chen M, Li Q-H and Bayley, H: Orientation of the monomeric porin OmpG in planar lipid bilayers. ChemBioChem 2008, 9(18):3029-36.

Hwang W, Chen M, Cronin B, Holden M and Bayley, H: Asymmetric droplet interface bilayers. J Am Chem Soc 2008, 130:5878-5879.

Chen M, Khalid S, Sansom M and Bayley H: Outer membrane protein G: engineering a quiet pore for biosensing. Proc Natl Acad Sci U S A 2008, 105: 6272-6277 (cover article). Comments in: Eisenberg B: Engineering channels: atomic biology. Proc Natl Acad Sci U S A 2008 Apr 29;105:6211-2.

Chen M, Abele R and Tampe R: Functional non-equivalence of ABC signature motifs in the transporter associated with antigen processing. J Biol Chem 2004, 279:46073-46081.

Chen M, Abele R and Tampe R: Peptides induce aTP Hydrolysis at both subunits of the transporter associated with antigen processing. J Biol Chem 2003, 278:29686-29692.

Janas E, Hofacker M, Chen M, Gompf S, van der Does C and Tampe R: The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem 2003, 278:26862-26869.

Heintke S, Chen M, Ritz U, Lankat-Buttgereit B, Koch J, Abele R, Seliger B and Tampe R: Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly. FEBS Lett 2003, 533:42-46.