|Lisa M. Minter
Professor of Veterinary & Animal Sciences, University of Massachusetts
Ph.D.: University of Massachusetts, 2001
Notch signaling in autoimmune diseases
My area of research focuses on the role Notch signaling plays in autoimmune responses. We are currently investigating how Notch signaling contributes to pathology and disease progression during immune-mediated bone marrow failure (BMF). We have established two new models of BMF, both of which are highly representative of the human immune-meditated BMF syndrome, Aplastic Anemia. In our first model, we transfer bulk splenocytes from a parental C57BL/6 strain into recipient mice that are the F1 hybrid progeny of a C57BL/6 x BALB/c cross. The result is a robust graft-versus-host response whereby the transferred splenocytes selectively target the bone marrow for destruction. The onset of disease is precipitous and symptoms include loss of repopulating stem cells from the bone marrow and immune cells from the periphery, infiltration of destructive CD4+ and CD8+ T cells into the recipient BM, as well as increased levels of the pro-inflammatory cytokines, interferon-g and TNF in the circulation.
Joshi, I, LM Minter, J Telfer, RM Demarest, AJ Capobianco, JC Aster, P Sicinski, A Fauq, TE Golde, and BA Osborne. Notch signaling mediates G1/S cell cycle progression in T cells (submitted).
JB Samon, A Champhekar, LM Minter, JC Telfer, L Miele, A Fauq, P Das, TE Golde and BA Osborne Notch1 and TGFb1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells (submitted).
Osborne, BA and LM Minter (2007) Notch signalling during peripheral T-cell activation and differentiation. Nat. Rev. Immunol. 7:64-75.
Shin, HM, LM Minter, OH Cho, S Gottipati, TE Golde, GE Sonenshein, and BA Osborne (2006) Notch-1 augments NF-κB activity by facilitating its nuclear retention. EMBO J. 25:129-38.
Minter, LM et al. (2005)Inhibitors ofg-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6:680-688.
Minter, LM, and BA Osborne (2003) Cell death in the thymus - it's all a matter of contacts. Seminars in Immunology 15:135-144.
Benson, RM, LM Minter, BA Osborne and EV Granowitz (2003) Hyperbaric oxygen inhibits stimulus-induced pro-inflammatory cytokine synthesis by human blood-derived monocyte-macrophages. Clinical and Experimental Immunology 134(1):57-62.
Minter, LM, ES Dickinson, SP Naber and DJ Jerry (2002) Epithelial cell cycling predicts p53-responsiveness to gamma-irradiation during post-natal mammary gland development. Development 129(12):2997-3008.
Jerry DJ, LM Minter, KA Becker and AC Blackburn (2002) Hormonal control of p53 and chemoprevention. Breast Cancer Research 4(3):91-4.