Gregory N. Tew

Associate Professor of Polymer Science and Engineering, University of Massachusetts

Email: tew@mail.pse.umass.edu

Ph.D.: University of Illinois, Urbana
Postdoctoral Training: University of Pennsylvania

Supramolecular Polymer Science

Macromolecular research in this century will be defined by discoveries at the interface of chemistry, biology, and materials science. Research in the Tew group is focused on problems at this interface. A common theme of all projects in the group is the use of modern synthetic organic chemistry to build interesting, novel macromolecules which are chemically rich and to study their properties using various physical methods. In one major thrust, we are interested in understanding how to program molecules with the necessary information to self-order into complex, hierarchical functional materials. Another thrust is elucidating the rules required to create biomimetics with structure and function rivaling proteins. This leads to materials with an array of interesting properties from sensors and magnetism to drug delivery and alkaline anion exchange membranes. Recent interests include novel water-soluble macromolecules for drug delivery and unique metal-containing polymers which are magnetic. We have new membranes for Li-ion conduction and novel polycations for alkaline fuel cell membranes. These endeavors are facilitated by intellectual creativity and significant scientific freedom is encouraged within the group. The group is composed of highly motivated students and we welcome your contributions in this exciting research endeavor. Students in the group are actively engaged in multi-disciplinary research, master many experimental techniques beyond synthetic methods, and are ideally positioned for future cutting-edge research positions in industry, academia, and government laboratories upon graduating from the group.

Representative publications:

Z. M. AL-Badri, R. R. Maddikeri, Y. Zha, H. D. Thaker, P. Dobriyal, R. Shunmuam, T. P. Russell, G. N. Tew, "Room Temperature Magnetic Materials from Nanostructured Diblock Copolymers," Nature Comms., 2, 482, (2011).

*S. Colak, G. N. Tew, "Dual-Functional ROMP-Based Betaines: the Effect of Hydrophilicity and Backbone Stucture on Non-Fouling Properties", Langmuir, 28, 666-675 (2012).

R. R. Maddikeri, S. Colak, S. P. Gido, G. N. Tew, “Zwitterionic Polymersomes in an Ionic Liquid: Room Temperature TEM Characterization,” Biomacromolecules (Communication), 12, 3412-3417, (2011).

J. M. Rathfon, R. W. Cohn, A. J. Crosby, J. P. Rothstein, G. N. Tew, "Confinement Effects on Chain Entanglement in Free-Standing Polystyrene Ultrathin Films," Macromolecules, 44, 5436-5442, (2011).

A. O. Tezgel, J. C. Telfer, G. N. Tew, “De Novo Designed Protein Transduction Domain Mimics from Simple Synthetic Polymers,” Biomacromolecules, 12, 3078-3083, (2011).

W. Hu, A. Som, G. N. Tew, "Interactions Between Lipids and Antimicrobial Oligomers Studied by Solid-State NMR," J. Phys. Chem B., 115, 8474-8480, (2011).

K. Zhang, M. A. Lackey, Y. Wu, G. N. Tew, "Universal Cyclic Polymer Templates," J. Am. Chem. Soc., 133, 6906-6909, (2011).

*A. Som, A. O. Tezgel, G. J. Gabriel, G. N. Tew, "Self Activation in De Novo Designed Mimics of Cell-Penetrating Peptides," Agnew. Chem., Int. Ed., 50, 1-5, (2011).

*K. Lienkamp, A. E. Madkour, G. N. Tew, "Antibacterial Peptidomimetics: Polymeric Synthetic Mimics of Antimicrobial Peptides," Adv. Polym. Sci., 1-32, (2011).

*K. Zhang, M. Lackey, J. Cui, G. N. Tew, “Gels Based on Cyclic Polymer,” J. Am. Chem. Soc., 133, 4140-4148, (2011).

*H. D. Thaker, F. Sgolastra, D. Clements, R. W. Scott, G. N. Tew, “Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds,” Journal of Medicinal Chemistry, 54. 2241-2254, (2011).

*A. E. Madkour, J. M. Grolman, G. N. Tew, "Synthesis of Hydrogels via Ring-Opening Metathesis Polymerization: Factors Affecting Gelation," Polym. Chem., 2, 114-119,
(2011)

J. M. Rathfon, R. W. Cohn, A. J. Crosby, G. N. Tew, “Hole Nucleation in Free-Standing Polystyrene Ultrathin Films, Macromolecules, 44, 134-139, (2011).

*K. Zhang, J. Cui, M. Lackey, G. N. Tew, "Hydrogels Based on Living Ring-Opening Metathesis Polymerization," Macromolecules, 43, 10246-10252, (2010).

S. K. Agrawal, N. Sanabria-DeLong, S. K. Bhatia, G. N. Tew, S. R. Bhatia, “Energetics of Association in Poly(lactic acid)-based Hydrogels with Crystalline and Nanoparticle-Polymer Junctions,” Langmuir, 26, 17330-17338, (2010).

*R. Shunmugam, G. J. Gabriel, K. A. Aamer, G. N. Tew, “Metal-Ligand-Containing Polymers: Terpyridine as the Supramolecular Unit,” Macromol. Rapid Comm., 31, 784-793, (2010).

*A. E. Madkour, A. H. R. Koch, K. Lienkamp, G. N. Tew, “End-Functionalized ROMP Polymers for Biomedical Applications,” Macromolecules, 43, 4557-4561, (2010).

*J. Jiang, M. M. Slutsky, T. V. Jones, G. N. Tew, “Apolar ortho-Phenylene Ethynylene Oligomers: Conformational Ordering without Intermolecular Aggregation,” New J. Chem., 34, 307-312, (2010).

G. N. Tew, R. W. Scott, M. L. Klein, W. F. DeGrado, “De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications,” Acc. Chem. Res., 43, 30-39, (2010).

J. A. Lamboy, J. A. Arter, K. A. Knopp, D. Der, C. M. Overstreet, E. F. Palermo, H. Urakami, T.-B. Yu, O. Tezgel, G. N. Tew, Z. B. Guan, K. Kuroda, G. A. Weiss, “Phage Wrapping with Cationic Polymers Eliminates Nonspecific Binding between M13 Phage and High p/Target Proteins,” J. Am. Chem. Soc., 131, 16454-16460, (2009).