Hang Xiao

Assistant Professor of Food Science, University of Massachusetts

Email: hangxiao@foodsci.umass.edu
H. Xiao Food Science Website

Ph.D.: University of Wisconsin-Madison
Postdoctoral Training: University of Wisconsin-Madison; Rutgers

Cancer Preventive Dietary Components, Diet-based Strategy for Cancer Prevention

Cancer is a leading cause of human death in the United States and most other industrialized countries. Epidemiological evidence has consistently indicated that diet abundant in fruits and vegetables may reduce the risk of cancer, and this effect has been attributed to bioactive components present in these foods. It was estimated that 30-70% of all cancer cases might be preventable by dietary modification, depending on the dietary components and specific type of cancer.

My research is focused on identifying potential cancer preventive dietary components (nutraceuticals), elucidating their molecular mechanisms, investigating possible synergistic interactions among these dietary components and commonly used pharmacological compounds, with the long-term goal of developing diet-based strategies for the prevention of cancer. The major approach of this research is the utilization of chemical, biochemical & molecular biology in cell cultures combined with in vivo animal models for human cancers.

Representative publications:

Liu, Y., Ju, J., Xiao, H., Simi, B., Hao, X., Reddy, B.S., Huang, M.T., Newmark, H. and Yang, C.S. (2008) Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats. Nutrition and Cancer, 60(5):660-5.

Xiao, H., and Yang, C.S. Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. International Journal of Cancer, 123(5):983-90.

Ju, J., Hao, X., Lee, M.J., Lambert, J., Lu, G., Xiao, H., Newmark, H., and Yang, C.S. (2008) γ-Tocopherol-rich mixed tocopherols inhibit colon tumorigenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prevention Research (In press).

Liu, Y., Xiao, H., Hao, X., Lee, H.J., Suh, N., Yang, C.S., Minden, A. (2008) The Pak4 protein is overproduced in tumors, and causes tumorigenesis in mice. Molecular Cancer Research 6(7):1215-24.

Xiao, H., Yang, C.S., Li, S., Jin, H., Ho, C., and Patel, T. (2008) Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung carcinoma cells by apoptosis. Molecular Nutrition and Food Research (In press).

Xiao, H., Hao, X., Simi, B., Jiang, H., Ju, J., Reddy, B., and Yang, C.S. (2008) Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis 29(1): 113-9.

Xiao, H., Zhang, Q., Lin, Y., Reddy, B., and Yang, C.S. (2008) Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. International Journal of Cancer 122(9):2115-24.

Lu, G., Xiao, H. (Co-first author), You, H., Lin, Y. Snagaski, B., and Yang, C.S. (2008) Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols (PPE) and atorvastatin. Clinical Cancer Research, 14(15):4981-8.

Yang, C.S., Ju, J., Lu, G., Xiao, H., Hao, X., Sang, S., and Lambert, J. (2008) Cancer prevention by tea and tea polyphenols. Asian Pacific Journal of Clinical Nutrition 17 Suppl 1:245-8.

Xiao, H. and Parkin, K.L. (2007) Isolation and identification of potential chemopreventive agents from methonalic extract of green onion (Allium spp.) guided by phase II enzyme bioassay. Phytochemistry 68(7):1059-67.

Suh, N., Paul S., Hao, X., Simi, B., Xiao, H., Ramando, A.M. and Reddy, B.S. (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clinical Cancer Research 13(1):350-5.

Xiao, H. and Parkin, K.L. (2006). Phase II enzyme induction by various selenium compounds. Nutrition and Cancer. 55:210-223.

Xiao, H. and Parkin, K.L. (2006). Isolation and identification of potential chemopreventive agents from non-polar extracts of green onion (Allium spp.) guided by phase II enzyme bioassay. J. Agric. Food Chem. 54(22):8417-24.