Leonard C. Norkin

Professor

Phone: 413-545-2009
Fax: 413-545-1578
Email: lnorkin@microbio.umass.edu
Mailing address

Ph.D.:Columbia University, New York, NY, 1969

Research Interests

Virology:

• Entry of simian virus 40 into cells via MHC class I molecules and caveolae
• SV40 as a gene delivery vector
  

Selected Publications

Norkin, L.C. (1999). Simian virus 40 infection via MHC class I molecules and caveolae. Immunological Reviews, 168:13-22.

Chen, Y., and Norkin, L.C. (1999). Extracellular Simian Virus 40 transmits a signal that promotes virus enclosure within caveolae. Experimental Cell Research 246:83-90.

Anderson, H.A., Chen, Y., and Norkin, L.C. (1998). MHC class I molecules are enriched in caveolae but do not enter with simian virus 40. Journal of General Virology 79:1469-1477.

Anderson, H.A., Chen, Y., and Norkin, L.C. (1996). Bound simian virus 40 translocates to caveolin-enriched membrane domains and its entry is inhibited by drugs that selectively disrupt caveolae. Molecular Biology of the Cell, 7:1825-1834.

Dangoria, N.S., Breau, W.C., Cishek, D.M., Anderson, H.A., and Norkin, L.C. (1996). Extracellular simian virus 40 induces an ERK/MAPK-independent signaling pathway that activates primary response genes and promotes virus entry. Journal of General Virology, 77:2172-2182.

Norkin, L.C., and Anderson, H.A. (1996). Multiple stages of virus-receptor interactions as shown by simian virus 40. Advances in Experimental Medicine and Biology, 408:159-167.

Norkin, L.C. (1995). Virus receptors: implications for pathogenesis and the design of antiviral agents. Clinical Microbiology Reviews 8:293-315.

Breau, W.C., W.J. Atwood, and Norkin, L.C. (1992). Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor. Journal of Virology 66:2037-2045.

Department of Microbiology
203 Morrill Science Center IVN
University of Massachusetts
639 North Pleasant Street
Amherst, MA 01003

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