Pablo Pomposiello

Lecturer

Phone: 413-577-4312
Fax: 413-545-1578
Email: ppomposi@microbio.umass.edu
Mailing address

Ph.D.: Biology, University of Michigan, 1997

Lab Group Home Page

Global transcriptional regulation in response to environmental stress

Our laboratory studies oxidative stress using bacterial models. We are particularly interested in global gene regulation in response to oxidative damage, and we use genetic and genomic approaches to understand antioxidant functions. Current projects include the whole-genome transcriptional profiling of E. coli's response to oxidative damage using gene arrays and the characterization of novel genes induced by oxidative stress and with possible roles in the repair of oxidative damage.

Selected Publications

Blanchard, J.L., Wholey, W., Conlon, E. and P. J. Pomposiello. (2007) Rapid changes in gene expression in response to superoxide reveal SoxRS-dependent and independent networks in E. coli. PloS One 2(11):e1186.

Osborne, M.J., Siddiqui, N., Landgraf, D., Pomposiello, P. J., and K. Gehring. (2005) The Solution Structure of the oxidative-stress related protein YggX from Escherichia coli.  Protein Science 14(6):1673-78.

P. J. Pomposiello, A. Koutsolioutsou, D. Carrasco and B. Demple. SoxS-mediated regulation and genetic analysis of the yggX gene of Escherichia coli. (2003) Journal of Bacteriology, 185:6624-6632.

P.J. Pomposiello and B. Demple. Global Responses to Free Radical Stress. (2002) Advances in Microbial Physiology. 46:319-341.

P.J. Pomposiello, M.E.J. Bennik and B. Demple. Genome-wide transcriptional profiling of the E. coli responses to superoxide and Sodium Salicylate. (2001) Journal of Bacteriology. 183:3890-3902.

P.J. Pomposiello and B. Demple. Redox-Operated Genetic Switches: the SoxR and OxyR Transcription Factors. (2001) Trends in Biotechnology. 19:109-114.

M.E.J. Bennik, PJ. Pomposiello, D.Thorne and B.Demple. Defining a rob Regulon in Escherichia coli Using Transposon Mutagenesis. (2000) Journal of Bacteriology. 182:3794-3801.

Department of Microbiology
203 Morrill Science Center IVN
University of Massachusetts
639 North Pleasant Street
Amherst, MA 01003

413 545 2051  |  Fax 413 545 1578

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