These are the courses currently taught or co-taught by Dr. Holden through the Microbiology department.

Microbial Physiology and Diversity (MICROBIO 480)

Co-taught with Dr. Kristen DeAngelis

Essential aspects of bacterial growth, including energy metabolism, macromolecular assemblages and functions, and the integration of metabolic processes by various regulatory mechanisms. Also the diversity of microorganisms, including origins of diversity, ecological and environmental pressures that create diversity, and how to measure diversity with examples from specific environments and microbial assemblages.

Level: Undergraduate
Credits: 3
Offered: Every spring semester
Prerequisites: General Microbiology (MICROBIO 310). Elementary Biochemistry (BIOCHEM 420) is recommended.

Integrative Experience: A Sea of Microbes (MICROBIO 494W)

Over 70% of the Earth's surface is covered with the oceans, and nearly all of the life within the ocean is microscopic. Some of these microbes are photosynthetic and form most of the base of the marine food web. These in turn are consumed by other small creatures that eventually provide food for the larger animals in the sea. Bacteria are responsible for maintaining certain chemical balances in the oceans, and themselves are food for other microbes. Understanding how life is sustained in our oceans is vital for coastal human populations that rely on the sea for food. Other people turn to marine microbes for new biotechnologies, or hope that by understanding them we might understand our own planet's climate history and how marine microbes will respond to global warming and ocean acidification.

Level: Undergraduate
Credits: 1 (of 3 required for IE in Microbiology)
Offered: Spring semester, 4 weeks
Prerequisites: General background in microbiology and biochemistry

Archaea Journal Club (MICROBIO 597A)

Description of the third domain of life known as the Archaea through weekly reading assignments and class discussion. We also discuss environments where archaea may play a prominent role.

Level: Graduate
Credits: 1
Offered: Fall semester
Prerequisites: General background in microbiology and biochemistry

Markers of Environmental Change (MICROBIO 597P)

Co-taught with Dr. Steve Petsch

Weekly readings of recent papers in geobiology and biogeochemistry, with students and faculty from the Microbiology and Geosciences departments.

Level: Graduate
Credits: 1
Offered: Spring semester
Prerequisites: General background in microbiology and/or geology

Advanced Microbial Physiology (MICROBIO 680)

Main aspects of microbial growth, energy and biosynthesis pathways, metabolic regulation and integration of pathways into a coherent system. Emphasis on physiological diversity, global control systems governing the adaptation of microorganisms to different environmental conditions, and emerging methodologies.

Level: Graduate
Credits: 3
Offered: Fall semester in odd years
Prerequisites: General background in microbiology and biochemistry