Nagendra Yadava
Adjunct Assistant Professor, Biology Department, University of Massachusetts
Scientist, Pioneer Valley Life Sciences Institute
Assistant Professor, Tufts University School of Medicine, Baystate Medical Center
Contact Info
Phone: 413-794-0786
Office:
Education
B.S., Banaras Hindu University, Varanasi, India, 1989
M.S., University of Baroda, Vadodara, India, 1991
Ph.D., Jawaharlal Nehru University, New Delhi, India, 1998
Postdoctoral
Buck Institute for Age Research, 2005-2008
Division of Biological Sciences, University of California San Diego, 1998-2005
Chicago Medical School, 1997-1998
Research Interests
Mitochondrial Diseases, Dysfunction, and Biogenesis; Apoptosis, Diabetes, Obesity, Breast Cancer, and Aging
For more information, please go to: http://www.pvlsi.org/lab_yadava.php
Representative Publications
Divakaruni, A.S., Wiley, S.E., Rogers, G.W., Andreyev, A.Y., Petrosyan, S., Loviscach, M., Wall, E.A., Yadava, N., Heuck, A.P., Ferrick, D.A., Henry R.R., McDonald, W.G., Colca, J.R., Simon, M.I., Ciaraldi, T.P., Murphy, A.N. 2013. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci.,,B> 110(14): 5422-7.
Yadava, N., Schneider, S., Jerry, D.J., Kim, C. 2013. Impaired mitochondrial metabolism and mammary carcinogenesis. J. Mammary Gland Biol., 18: 75-87.
Compton, C., Kim, C., Griner, N.B., Potluri, P., Scheffler, I.E., Sen, S., Jerry, D.J., Schneider, S., Yadava, N. 2011. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J. Biol. Chem., 286(23): 20297-20312.
Gerencser, A.A., Neilson, A., Choi, S.W., Edman, U., Yadava, N., Oh, R.J., Ferrick, D.A., Nicholls, D.G., Brand, M.D. 2009. Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion. Anal. Chem., 81: 6868-6878.
Amo, T., Yadava, N., Oh, R., Nicholls, D.G., Brand, M.D. 2008. Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene, 411(1-2): 69-76.
Yadava, N., Nicholls, D.G. 2007. Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity following partial respiratory inhibition of mitochondrial complex I with rotenone. J. Neurosci., 27(27): 7310-7317.
Potluri, P., Yadava, N., Scheffler, I.E. 2004. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur. J. Biochem., 271: 3265-3273.
Ricci, J.E., Munoz-Pinedo, C., Fitzerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., Green, D.R. 2004. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit (NDUFS1) of complex I of the electron transport chain. Cell, 117: 773-786.
Yadava, N., Scheffler, I.E. 2004. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion, 4: 1-12.
Yadava, N., Houchens T., Potluri P., Scheffler I.E. 2004. Development and characterization of a conditional mitochondrial complex I assembly system. J. Biol. Chem., 279(13): 12406-12413.
Yadava, N., Potluri, P., Smith, E., Bisevac, A., Scheffler, I. E. 2002. Species-specific and mutant MWFE proteins: their effect on the assembly of the mammalian mitochondrial complex I. J. Biol. Chem., 277(24): 21221-30; 277(45): 21221-21230.
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