Research Interests

Mitochondrial Diseases, Dysfunction, and Biogenesis; Apoptosis, Diabetes, Obesity, Breast Cancer, and Aging

For more information, please go to: http://www.pvlsi.org/lab_yadava.php

Representative Publications

Divakaruni, A.S., Wiley, S.E., Rogers, G.W., Andreyev, A.Y., Petrosyan, S., Loviscach, M., Wall, E.A., Yadava, N., Heuck, A.P., Ferrick, D.A., Henry R.R., McDonald, W.G., Colca, J.R., Simon, M.I., Ciaraldi, T.P., Murphy, A.N. 2013. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci.,,B> 110(14): 5422-7.

Yadava, N., Schneider, S., Jerry, D.J., Kim, C. 2013. Impaired mitochondrial metabolism and mammary carcinogenesis. J. Mammary Gland Biol., 18: 75-87.

Compton, C., Kim, C., Griner, N.B., Potluri, P., Scheffler, I.E., Sen, S., Jerry, D.J., Schneider, S., Yadava, N. 2011. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J. Biol. Chem., 286(23): 20297-20312.

Gerencser, A.A., Neilson, A., Choi, S.W., Edman, U., Yadava, N., Oh, R.J., Ferrick, D.A., Nicholls, D.G., Brand, M.D. 2009. Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion. Anal. Chem., 81: 6868-6878.

Amo, T., Yadava, N., Oh, R., Nicholls, D.G., Brand, M.D. 2008. Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene, 411(1-2): 69-76.

Yadava, N., Nicholls, D.G. 2007. Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity following partial respiratory inhibition of mitochondrial complex I with rotenone. J. Neurosci., 27(27): 7310-7317.

Potluri, P., Yadava, N., Scheffler, I.E. 2004. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur. J. Biochem., 271: 3265-3273.

Ricci, J.E., Munoz-Pinedo, C., Fitzerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., Green, D.R. 2004. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit (NDUFS1) of complex I of the electron transport chain. Cell, 117: 773-786.

Yadava, N., Scheffler, I.E. 2004. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion, 4: 1-12.

Yadava, N., Houchens T., Potluri P., Scheffler I.E. 2004. Development and characterization of a conditional mitochondrial complex I assembly system. J. Biol. Chem., 279(13): 12406-12413.

Yadava, N., Potluri, P., Smith, E., Bisevac, A., Scheffler, I. E. 2002. Species-specific and mutant MWFE proteins: their effect on the assembly of the mammalian mitochondrial complex I. J. Biol. Chem., 277(24): 21221-30; 277(45): 21221-21230.