Biology Undergrad and Post-doc Publish in Current Biology

Biology Department researchers led by Wei-Lih Lee have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in chromosome- and spindle positioning wasn’t known before. Asymmetric cell division is important in the self-renewal of stem cells and because it ensures that daughter cells have different fates and functions.

Lee and postdoctoral researcher Steven Markus, with undergraduate Junior Fellow Katelyn Kalutkiewicz, identified She 1 as the first known regulator of asymmetric cell division that inhibits the dynein engine, but surprisingly also promotes asymmetric division. Their work will appear in the December 4 print edition of Current Biology and is supported by the NIH’s National Institute of General Medical Sciences.

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