Circadian rhythms and estrous cycles

A master circadian pacemaker in the hypothalamus controls not only rhythms of sleep and wakefulness but also neuroendocrine functions including the estrous cycle in mice and hamsters. By studying mutants and conditional knockouts, we examine the roles of specific genes and their protein products in the brain circuitry that generates the preovulatory surge of luteininzing hormone (LH) from the anterior pituitary. Projects require handling of animals in order to track estrous cycles, ovariectomy, hormone assays, PCR genotyping, and immunostaining (with quantitative neuroanatomical analyses).

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