16-20

Genetics and molecular mechanisms of host-microbe mutualism

The Wang Lab, located in the Life Science Laboratories, is interested in the mechanisms of beneficial host-microbe interactions. Our experimental system is the symbiosis between legumes and nitrogen-fixing rhizobia, with important economic and environmental relevance, as well as similarities to pathogenic interactions. The BURA student will be engaged in dissecting the genetic basis of the nitrogen-fixing symbiosis, in particular characterizing the defects in host mutants unable to sustain a successful symbiotic relationship.

Zebrafish Neural Stem Cells and Brain Growth

The Karlstrom Lab investigates the formation and growth of the forebrain and pituitary gland in the zebrafish. We are examining how cell-cell signaling controls stem cell proliferation to regulate tissue growth and cell renewal in larvae and adults. This position is for students ready to pursue a serious honors thesis project, including summer research. The student will begin by quantifying normal brain growth during larval development using a series of fluorescent transgenic zebrafish lines.

Zebrafish Neurobiology: Fluorescent transgenics and brain development

The Karlstrom Lab investigates the formation and growth of the ventral forebrain in the zebrafish. We have created/collected a large number of transgenic lines that allow us to 1) document gene expression domains in the brain and 2) study how cell-cell signaling systems control forebrain development and growth. This entry-level undergraduate project is to work with a graduate student to maintain these zebrafish transgenic lines and use fluorescence microscopy to examine gene expression patterns in the brain.

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