What Makes a Good Model System?
Model biological system philosophy:
We are unlikely to ever know everything about every organism.
Therefore, we should agree on some convenient organism(s) to study in great
depth, so that we can use the experience of the past (in that organism)
to build on in the future. This will lead to a body of knowledge in
that 'model system' that allows us to design appropriate studies of
non-model systems to answer important questions about their biology.
Historical statements of the philosophy:
Criteria for a model biological system:
- Is the organism used easy to rear?
- Is its rearing/operation size convenient?
- Is it inexpensive to operate?
- Does the organism used have short life cycle?
- Is the organism used geneticly manipulable?
- Does it promise economically important results?
- Dose it have an audience of interested people?
- Interactions between criteria.
- Visit the E. coli
- Visit the
Neurospora genome project
-or- visit the
- Fission yeast,
Saccharomyces Genome Database, SGD
- The plant, Arabidopsis, an NIH and NSF approved Model System.
- Plant Pollen Tubes:
- Explore the viruses, virology -or-
A practical use of a virus as a model
- The Lobster Cuticle Composite-Material Model
- The cockroach homepage: BlattaBase
- The fruitfly Drosophila melanogaster
FlyBase at Indiana - or -
The Interactive Fly
- The cellular slime mold, dictyBase
- The Mosquito malaria model. |
Tissue model of infection. |
Dengue early warning system! |
Disease risk. |
- Zebra fish, Brachydanio rerio at ZFIN
- Original NIH Sponsorship
- Surf Clams, Spisula solidissima, as a model system.
- African clawed toad, Xenopus laevis, Xenbase
- nematode, C. elegans
- Visit the Jackson Laboratory, source of mutant
mice, Mus musculus. |
Diet Induced Obesity model.|
- Injury models:
- Non-Human Primate Models... The Macaque:
- A model ecological system,
lynx hare population dynamics
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