Selected Publications

Male, I, Ozacar, A.T., Fagan, R.R., Loring, M.D., Shen, M-S., Pace, V.A., Devine, C.A., Lawson, G.E., Lutservitz, A., and Karlstrom R.O. (in press) Hedgehog signaling regulates neurogenesis in the larval and adult zebrafish hypothalamus. eNeuro.  
Navon, D, Male, I, Tetrault, E.R., Aaronson, Benjamin, KarlstromR.O.and Craig Albertson (2020) Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity. Proc. Natl. Acad. Sci. USA. 2020 Aug 11;117(32):19321-19327.
Tonyushkina KN, Shen MC, Ortiz-Toro T, Karlstrom R.O. (2017) Low thyroid hormone levels disrupt thyrotrope development. Endocrinology 2017 Sep 1;158(9):2774-2782. doi: 10.1210/en.2016-1935.
Breves, JP, McCormick, S, and Karlstrom, R. 2014. Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia. General and Comparative Endocrinology 203:21-28.
Tonyushkina, K, Shen, M-C, Ortiz-Toro, T., and Karlstrom, R.O. 2014. Embryonic exposure to excess thyroid hormone causes thyrotrope cell death. Journal of Clinical Investigation 124:321-327.
Shen, M.C., Ozacar, A.T, Boeras, C, Pink, J., Thomas, J., Kohtz, J., and Karlstrom R.O.  2013.  Heat Shock Mediated Conditional Regulation of Hedgehog/Gli Signaling in Zebrafish. Developmental Dynamics, 242(5): 539-49.
Breves JP, Serizier SB, Goffin V, McCormick SD, Karlstrom R.O., (2013) Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill. Mol Cell Endocrinol. 369(1-2):98-106
Choi WY, Gemberling M, Wang J, Holdway JE, Shen MC, Karlstrom R.O., Poss KD. (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 2013 140(3):660-6.
Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) brother of CDO(umleitung) is cell autonomously required for Hedgehog mediated ventral CNS patterning in the zebrafish Development, 138(1):75-85.
Barresi. M.J.F., Burton, S., DiPietrantonio, K., Amsterdam, A., Hopkins, N., Karlstrom, R.O. (2010)  Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev. Dyn. 239:2603-18
Placinta, M., Shen, MC., Achermann, M., and Karlstrom, R.O. (2009) A laser-pointer driven optical microheater for conditional gene regulation in Zebrafish. BMC Developmental Biology 9:73
Wang, Z, Glenn, H, Brown, C, Valavanis, C, Liu, J-X, Seth, A, Thomas, J.E, Karlstrom, R.O., and Schwartz, L.M. (2009) Regulation of muscle differentiation and survival by Acheron. Mechanisms of Development. 126(8-9):700-9
Devine, C.A., Sbrogna, J.L., Guner, B. Osgood, M., Shen, M-C., and Karlstrom, R.O. (2009) A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Developmental Biology. 326(1):143-54
Guner, B. Ozacar, A.T., Thomas, J.E. and Karlstrom, R.O. (2008) Graded Hh and Fgf signaling independently regulate pituitary cell fates and help establish the PD and PI of the zebrafish adenohypophysis. Endocrinology. 149(9):4435-51
Bergeron, S.A., Milla, L.A., Villegas, R., Shen, M-C., Burgess, S.M., Allende, M.L., Karlstrom, R.O., and Palma, V. (2008) Expression profiling identifies novel Hh/Gli regulated genes in developing zebrafish embryos. Genomics 91(2):165-77
Guner, B. and Karlstrom, R.O. (2007) Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube.  Mechanisms of Development. 7(5):596-605
Seth, A, Culverwell, J, Walkowicz, M., Toro, S., Rick, J.M., Neuhauss, S., Varga, Z., and Karlstrom, R.O. (2006) belladonna/lhx2 is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development. 133;725-735
Cerda, G.A., Thomas, J.E., Allende, M.A., Karlstrom, R.O., Palma, V. (2006). Electroporation of DNA, RNA, and morpholinos into zebrafish embryos. Methods 39;207-211
Barresi, M.J., Hutson, L. Chien, C-B., and Karlstrom, R.O. (2005) Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development, 132(16); 3643-56
Vanderlaan, G.M., Tyurina, O.V., Karlstrom, R.O., and Chandrasekhar, A., (2005) Gli Function is Essential for Motor Neuron Induction in Zebrafish. Developmental Biology, 282(2);550-70
Tyurina, O.V., Guner, B., Popova, E., Feng, J., Schier, A.F., Kohtz, J.D., and Karlstrom, R.O. (2005) Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Developmental Biology 277; 537-56.
Feng, J., White, B., Tyurina, O., Guner, B., Larson, T., Lee, H., Karlstrom, R. O., and Kohtz, J. (2004). Synergistic and antagonistic roles of the Sonic hedgehog N and C-terminal lipids. Development 131(17):4357-70.
Sekimizu, K, Nishioka, N, Sasaki, H, Takeda, H, Karlstrom, R.O. and Kawakami, A. (2004).. The zebrafish iguana locus encodes Dzip1, a novel zinc finger protein required for proper regulation of hedgehog signaling. Development 131: 2521-2532.
Sbrogna, J.L., Barresi, M.J.F., and Karlstrom, R.O. (2003) Multiple roles for hedgehog signaling in zebrafish pituitary development.  Dev. Biology. 254:19-35.
Karlstrom, R.O., Tyurina, O., Kawakami, A., Nishioka, N., Talbot, W.S., Sasaki, H., and Schier, A.F. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development.  Development. 130:1549-1564
Culverwell, J, and Karlstrom, R.O. (2002) Making the connection: Retinal axon guidance in the zebrafish.  Sem. Cell and Developmental Biol. 13:497-506 (review).
diIorio, P, Moss, J.B., Sbrogna, J.L, Karlstrom, R.O., and Moss, L.G. (2002) Sonic hedgehog is required early in pancreatic islet development.  Dev. Biology. 244:75-84
Kondoh, H., Ukhikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., and Karlstrom, R.O. (2000) Zebrafish mutations in gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage.  Mechanisms of Development. 96:165-174.
Karlstrom, R.O., Talbot, W.S, and Schier, A.F. (1999) Comparative synteny cloning of zebrafish you-too: Mutations in the hedgehog target gli2 affect ventral forebrain patterning.  Genes and Development. 13:388-393.
Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic Analysis of Axon Guidance in the Zebrafish.  Trends in Neurosciences. 20:3-8 (review).
Karlstrom, R.O., Trowe, T.,  Klostermann, S., Baier, H., Brand, M. Crawford, A.D., Grunewald, B., Hafter, P., Hoffmann, H., Meyer, S.U., Müller, B.K., Richter, S., van Eeden, F.J.M., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996)  Zebrafish mutations affecting retinotectal axon pathfinding.  Development 123:427-438.
Karlstrom, R.O. and Kane, D.A. (1996) A time-lapse flip-book of zebrafish development.  Development 123:2-460.
Brand, M., Heisenberg, C.-P., Beuchle, D., Jiang, Y.-J., Karlstrom, R.O., Warga, R.M., Pelegri, F., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Kelsh, R.N., Mullins, M.C., Odenthal, J. and Nüsslein-Volhard, C. (1996)  Mutations affecting development of the spinal cord and general body shape during zebrafish embryogenesis.  Development 123:129-142.
Karlstrom, R.O., Wilder, L.P., and Bastiani, M.J. (1993)  Lachesin: An immunoglobulin superfamily protein whose expression correlates with neurogenesis and axon outgrowth in grasshopper embryos.  Development. 118:509-522.
Bastiani, M.J., de Couet, H.G., Quinn, J.M.A., Kotrla, K.J., Karlstrom, R.O., Goodman, C.S., and Ball, E.E. (1992) Transient and dynamic expression of the MEG protein during development of the grasshopper embryo.  Dev. Biology 154:129-142.
Zafaralla, G.C., Ramilo, C., Gray, W.R., Karlstrom, R.O., Olivera, B.M., and Cruz, L. (1988)  Phylogenetic specificity of cholinergic ligands: alpha-conotoxin S1.  Biochemistry 27:7102-7105.